N-(2-(1-(2-((2,3-Dihydro-1H-inden-5-yl)amino)-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-N-methylbenzamide - Names and Identifiers
N-(2-(1-(2-((2,3-Dihydro-1H-inden-5-yl)amino)-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-N-methylbenzamide - Physico-chemical Properties
| Molecular Formula | C28H28N4O2
|
| Molar Mass | 452.56 |
| Density | 1.23±0.1 g/cm3(Predicted) |
| Boling Point | 731.6±60.0 °C(Predicted) |
| Solubility | DMSO : 100 mg/mL |
| pKa | 14.05±0.20(Predicted) |
| Storage Condition | -20℃ |
| Use | GSK717 is a potent, selective inhibitor of NOD2 (nucleotide-binding oligomeric domain 2). GSK717 inhibits NOD2-mediated signal transduction induced by mural acyl dipeptide (MDP), and the IC50 in the secretion IL-8 of HEK293/hNOD2 cells stimulated by MDP is 400 nM. |
| In vitro study | GSK717 blocks synergy between NOD2 and TLR2. GSK717 does not affect NOD1, TNFR1 and TLR2-mediated responses. GSK717 (5 μM) inhibits the release of IL-8, IL-6, TNFα and IL-1β in primary human monocytes stimulated with MDP. |
N-(2-(1-(2-((2,3-Dihydro-1H-inden-5-yl)amino)-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-N-methylbenzamide - Reference
| Reference Show more | 1. Rickard DJ, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. PLoS One. 2013;8(8):e69619. Published 2013 Aug 1. |
N-(2-(1-(2-((2,3-Dihydro-1H-inden-5-yl)amino)-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-N-methylbenzamide - Preparation solution concentration reference
| | 1mg | 5mg | 10mg |
|---|
| 1 mM | 2.21 ml | 11.049 ml | 22.097 ml |
| 5 mM | 0.442 ml | 2.21 ml | 4.419 ml |
| 10 mM | 0.221 ml | 1.105 ml | 2.21 ml |
| 5 mM | 0.044 ml | 0.221 ml | 0.442 ml |
Last Update：2024-01-02 23:10:35
N-(2-(1-(2-((2,3-Dihydro-1H-inden-5-yl)amino)-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-N-methylbenzamide - Reference Information
| biological activity | GSK717 is an effective and selective NOD2 (nucleotide binding oligomeric domain 2) inhibitor. GSK717 inhibits NOD2-mediated signal transduction induced by mural acyl dipeptide (MDP), and the IC50 in the secretion IL-8 of HEK293/hNOD2 cells stimulated by MDP is 400 nM. |
| in vitro studies | GSK717 blocks synergy between NOD2 and TLR2. GSK717 doesnot affect NOD1, TNFR1 and TLR2-mediated responses. GSK717 (5 μM) inhibits the release of IL-8, IL-6, TNFα and IL-1β in primary human monocytes stimulated with MDP. |
Last Update：2024-04-09 20:48:19
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